| 肝癌介入治疗药动学及其临床意义探讨 |
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| 引用本文： | 刘平,曾伟华,李后炳,潘云艳,杜运生. 肝癌介入治疗药动学及其临床意义探讨[J]. 介入放射学杂志, 1995, 0(2) |
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| 作者姓名： | 刘平 曾伟华 李后炳 潘云艳 杜运生 |
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| 作者单位： | 湖南湘潭市中心医院,湖南湘潭市中心医院,湖南湘潭市中心医院,湖南湘潭市中心医院,湖南湘潭市中心医院 |
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| 摘 要： | 本研究通过测定血清阿霉素浓度,分析了原发性肝癌阿霉素肝动脉灌注(A 组)、阿霉素碘油乳化后栓塞(B 组)及阿霉素微囊栓塞化疗(C 组)后药动学变化及其临床意义。A 组药动学变化与静脉给药相似,但峰值浓度高。B 组峰浓度低,半衰期延长,显示缓释和降低血浓度的作用。C 组峰浓度不明显,表现为长时、稳定的释放,血浓度低,具有保持局部长时间高浓度作用。结果揭示了肝癌介入治疗不同给药方法疗效差异的药动学依据。
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| 关 键 词： | 肝癌 动脉 栓塞 阿霉素 微囊 药动学 |
Study on Pharmacokinetics of Adriamycin(ADR)and Its Clinical Significance in Interventional Therapy for Hepatocellular Carcinoma |
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| Liu Ping Xiang Tan City Centre Hospital,Hunan Province. Study on Pharmacokinetics of Adriamycin(ADR)and Its Clinical Significance in Interventional Therapy for Hepatocellular Carcinoma[J]. Journal of Interventional Radiology, 1995, 0(2) |
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| Authors: | Liu Ping Xiang Tan City Centre Hospital Hunan Province |
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| Abstract: | Studies of pharmacokinetics and its clinical significance were done on adriamycin(ADR)introduced by interventional procedures for hepatocellular carcinoma. Patients were divided into 3 groups;group A,for hepatic arterial infusion of ADR;group B,for hepatic arterial embolization with ADR-lipiodol emulsion;group C,for hepatic arteri- al embolization with ADR-microcapsule.The results showed the pharmacokinetics in group A was similar to that of intravenous injection with high peak concentration;the peak serum concentration of ADR in group B was much lower than that in group A,with prolonged half-life attenation slowing the benefits of sustained-releases and reduction of blood drug concentration fabourable for reducing toxicity-side effect.Serum concentration of ADR in group C appeared in a"static state"of steady release.With low blood concentration favor- able for keeping high concentration in target tissue,reducing toxicity-side effects and en- hancing anticancer effect. |
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| Keywords: | Liver cancer Artery embolization Adriamycin Microcapsule Pharmacokinetics |
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