| 延胡索乙素对大鼠脑缺血再灌注损伤的影响 |
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| 引用本文： | 闵清,李立中,吴基良,江翠娥,王秋桂.延胡索乙素对大鼠脑缺血再灌注损伤的影响[J].咸宁医学院学报,1995,9(4):151-153. |
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| 作者姓名： | 闵清 李立中 吴基良 江翠娥 王秋桂 |
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| 作者单位： | 咸宁医学院药理学教研室(闵清，李立中，吴基良)，咸宁医学院组织胚胎学教研室(江翠娥，王秋桂) |
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| 摘 要： | 利用大鼠脑缺血再灌注损伤模型,观察延胡索乙素（THP）对脑缺血再灌注损伤的保护作用,实验结果表明,THP能使脑缺血再灌注过程中超氧化物歧化酶（SOD）活力（P<0.01）和谷胱甘肽过氧化物酶（GSHPx）活力（P<0.05）明显升高、脂质过氧化物产物丙二醛(MDA)明显下降（P
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| 关 键 词： | 脑缺血再灌注损伤 THP 延胡索乙素 大鼠 脂质过氧化物 保护作用 升高 制氧 产物 机理 |
Effects of Tetrahydropalmatine on Ischemia-Reperfusion-Induced Brain Injury in Rats |
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| Min Qin,et al.Effects of Tetrahydropalmatine on Ischemia-Reperfusion-Induced Brain Injury in Rats[J].Journal of Xianning Medical College,1995,9(4):151-153. |
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| Authors: | Min Qin |
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| Institution: | Min Qin,et al Department of Pharmacology |
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| Abstract: | In order to observe the protective effects of Tetrahydropalmatine (THP) on ischemia-reperfusion-induced brain injury; a model was set up by using ischemia-reperfusion induced brain injury i Rate. The date show that superoxide dismutase (SOD) activity (P<0.01)and Giutathione peroxidase (GSHTX) activity (P<0.05) were increased and Malondialehyde(MDA) Was decreased (P<0.01) decreasing 42.5%; and the activities of Na -K -ATPase and Ca2 -ATPase were increased (P<0.05) during brain ischemia-reperfusion. The result suggested that THP has protective effect on ischemia-reperfusion-induced brain probably by inhibiting oxygen free radicals and subsequent lipid peroxidation |
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| Keywords: | Tettrhydropalmatine (THP) Brain ischemia Reperfusion injury |
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