Changes in cerebral blood flow, intracranial and cerebral perfusion pressure in neurosurgical patients during anesthesia induced with diprivan

Effect of diprivan on cerebral blood flow, intracranial (ICP) and cerebral perfused pressure (CPP) was studied in neurosurgical patients during induction narcosis. The labored perfusion syndrome was observed in all patients during the initial stage. Infusion of diprivan at the initial stage of narcosis in a dose of 2 mg/kg led to a decrease in arterial pressure, mean arterial pressure, CPP, and ICP. During intubation ICP decreased by 3-7 mm Hg. At the stage of anesthesia stabilization ICP decreased by 27.3%, mean arterial pressure by 10%, CPP by 6%, linear blood flow velocity in the mid-cerebral artery of the intact hemisphere by 28.1% and in the involved hemisphere by 39.9%, with simultaneous leveling of cerebral blood flow between them.