Botulinum toxin in the treatment of orofacial tardive dyskinesia: a single blind study |
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Authors: | Slotema Christina W van Harten Peter N Bruggeman Richard Hoek Hans W |
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Affiliation: | Parnassia Psychiatric Institute, Mangostraat 15, NL-2552 KS The Hague, The Netherlands. |
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Abstract: | OBJECTIVE: Orofacial tardive dyskinesia (OTD) is difficult to treat and Botulinium Toxin A (BTA) may be an option. METHODS: In a single blind (raters were blind) study (N=12, duration 33 weeks) OTD was treated with Botulinum Toxin A in three consecutive sessions with increasing dosages. The severity was measured with the Abnormal Involuntary Movement Scale (AIMS). RESULTS: Overall there was a non-significant reduction in the severity of OTD (p=0.15). However, in the patients with no change in their antipsychotic medication (N=8) the reduction was significant (p=0.035). After the study, 50% of the patients preferred to continue the Botulinum Toxin A treatment. CONCLUSION: BTA was well tolerated and showed a non-significant improvement for OTD. A larger double blind study is warranted. |
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Keywords: | AIMS, Abnormal Involuntary Movement Scale BTA, Botulinum Toxin A OTD, Orofacial Tardive Dyskinesia TD, Tardive Dyskinesia |
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