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| 苯妥英钠对人精子染色体结构畸变的体外实验 | |
| 引用本文： | 蒙华庆,张逢春,高小平,王学峰,李丹,崔晓,沈鼎烈,王增产. 苯妥英钠对人精子染色体结构畸变的体外实验[J]. 中华医学遗传学杂志, 2001, 18(4): 303-305 |
| 作者姓名： | 蒙华庆 张逢春 高小平 王学峰 李丹 崔晓 沈鼎烈 王增产 |
| 作者单位： | 1. 重庆医科大学附属第一医院精神科, 2. 四川省计划生育科研所 3. 四川省计划生育科研所神经内科 4. 四川省计划生育科研所神经内科计划生育系 |
| 基金项目： | 国家自然科学基金(39270810) |
| 摘 要： | 目的：检测苯妥英钠对人精子染色体的诱变效应。方法：应用人精子染色体离体测试系统检测苯妥英钠在3种不同浓度对人精子染色体的损伤作用，并与平阳霉素的阳性对照组和空白对照组比较。结果：苯妥英钠在10μg/ml、20μg/ml、40μg/ml3种浓度的染色体结构畸变精子率和断裂数均较空白对照组高，但仅40μg/ml组的增高，差异有显著性。结论：苯妥英钠对人精细胞可能具有潜在的诱变危害性。 |
| 关 键 词： | 苯妥英钠 精子 染色体结构畸变 实验研究 抗癫痫药 |
| 修稿时间： | 2001-02-18 |
Effects of phenytoin on structural aberration of human sperm chromosomes in vitro |
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| H Meng,F Zhang,X Gao,X Wang,D Li,X Cui,Z Wang. Effects of phenytoin on structural aberration of human sperm chromosomes in vitro[J]. Chinese journal of medical genetics, 2001, 18(4): 303-305 | |
| Authors: | H Meng F Zhang X Gao X Wang D Li X Cui Z Wang |
| Affiliation: | Department of Psychiatry, the First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016 P.R.China. MHQ99666@sina.com |
| Abstract: | OBJECTIVE: To detect the mutagenic effects of phenytoin on human sperm chromosomes. METHODS: The mutagenic effects of phenytoin at 10, 20 and 40 microgram/ml were tested by an in vitro testing system of human sperm chromosomes, with leomycin A5 as a positive control and mutagen-free solution as the blank control. RESULTS: The frequencies of sperm with structural chromosomal aberrations and breakages of sperm chromosomes in the groups of 10 microgram/ml, 20 microgram/ml and 40 ug/ml of phenytoin were all higher than those in the blank control, but only in the group of 40 ug/ml, the elevated frequencies were statistically significant (P<0.005, P<0.05). CONCLUSION: Phenytoin has probably mutagenic potential effect on human sperm cells. |
| Keywords: | phenytoin sperm structural chromosomal aberration |
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