Significant heterogeneity in the geographical distribution of diffuse grade II/III gliomas in France |
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| Authors: | Amélie Darlix Sonia Zouaoui Jean-Marc Virion Valérie Rigau Hélène Mathieu-Daudé Marie Blonski German Reyes-Botero Faiza Bessaoud Brigitte Trétarre Fabienne Bauchet Laurent Capelle Michel Fabbro Christine Kerr Dominique Figarella-Branger Hugues Duffau Luc Taillandier Luc Bauchet |
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| Institution: | 1. Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1136, New York, NY, 10029, USA
2. Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA
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| Abstract: | The recognition of stem cells (SC) in the adult CNS and in association with gliomas has spawned an entire field of research and intense investigation. A large body of knowledge is being accumulated to gain insight into the pathobiology of gliomas with the intent of finally improving the grave prognosis that continues to beset patients with high grade gliomas (HGG). In this article, we provide a historical overview of the events leading to the discovery of SC and glioma stem cells (GSC). We then focus on the current understanding of GSC with respect to markers, clinical significance, and their targeting. We discuss current data and developments using SC as vehicles to delivery therapeutic agents to HGG. We conclude with a discussion of opportunities for future development and concepts aimed at reducing tumor recurrence and improving survival for patients with HGG. |
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