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White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder |
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| Authors: | Miriam Cooper Anita Thapar Derek K. Jones |
| Affiliation: | 1. Child and Adolescent Psychiatry Section, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Second Floor, Hadyn Ellis Building, Maindy Road, Cathays, Cardiff, CF24 4HQ, UK 2. MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK 3. Cardiff University Brain Research Imaging Centre, Cardiff University School of Psychology, Cardiff, UK 4. Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK |
| Abstract: | Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case–control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD. |
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