急性脑梗死患者血浆D-D变化及其与Hcy的关系

目的：研究血浆D-二聚体（D-D）水平和同型半胱氨酸（Hcy）水平分别在脑梗死和脑出血患者中的临床意义及其两者之间的相关关系。方法：对397例脑梗死患者和122例脑出血患者分别应用全自动化学发光分析仪（ASCl80SE）测定血浆Hcy和应用ELISA双抗体夹心法测定血浆D-D,并分析两者之间的相关关系。结果：①脑梗死患者的血浆D-D为（5.20±0.92）μg/L,Hcy为（21.23±13.54）μmol/L,均显著高于脑出血患者和对照组。②脑梗死组中D-D增高101例（25.4%）,Hcy增高140例（35.3%）,分别高于脑出血组中的17例（13.9%）和27例（22.1%）,均为P〈0.01。③脑梗死患者的血浆D-D和Hcy水平之间r=-0.0185,P〉0.05;而脑出血组为r=0.0742,P〉0.05。④脑梗死患者的血浆D-D水平无性别和年龄差异。血浆Hcy水平男性高于女性,但无年龄差异。结论：脑梗死患者的血浆D-D和Hcy水平均明显增高,但两者之间无相关性。

Study on the Change and Relationship Between Plasma D-Dimer and Homocysteine Levels in Patients with Acute Cerebral Vascular Accident

Objective To study the clinical significance of the changes and the relationships between plasma D-dimer（D-D） and Homocysteine（Hcy） expression in patients with acute cerebral infarction and acute cerebral hemorrhage.Methods Plasma D-D（with ELISA） and Hcy（with CLIA） levels were measured in 397 patients with cerebral infarction,122 patients with cerebral hemorrhage and 30 controls.Results ① The mean level of the plasma D-D and Hcy in patients with acute cerebral infarction was 5.20±0.92μg/L and 21.23±13.54 μmol/L respectively,which was significant higher than that in controls and patients with acute cerebral hemorrhage.② Higher expressing of D-D and Hcy was found in 101（25.4%） and 140（35.3%） cases of acute cerebral infarction patients.The data in acute cerebral hemorrhage group was 17（13.9%） and 27（22.1%） respectively.There was significant difference between two groups,P〈0.01.③ There was not correlations with the expression level of D-D and Hcy in patients with acute cerebral infarction and patients with acute cerebral hemorrhage.④ The expressing level of the Plasma D-D in acute cerebral infarction patients was not significant difference in both age and sex.The expressing level of Hcy in male was higher than that in female.There was not significant difference in the expressing level of Hcy in different age.Conclusion The levels of plasma D-D and Hcy in patients with acute cerebral infarction significantly in creased,but there were not correlations between the levels of the two parameters.