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| 肝内胆管癌转化治疗 | |
| 引用本文： | 赵海涛,杨 旭. 肝内胆管癌转化治疗[J]. 中国实用外科杂志, 2020, 40(6): 732-737. DOI: 10.19538/j.cjps.issn1005-2208.2020.06.23 |
| 作者姓名： | 赵海涛 杨 旭 |
| 作者单位： | 北京协和医院肝脏外科，北京100630 |
| 基金项目： | 国际科学技术合作项目(No.2016YFE0107100,No.2015DFA30650);CAMS临床和转化医学研究基金(No.2019XK320006);CAMS医学创新基金(CIFMS)(No.2017-I2M-4-003,No.2018-I2M-3-001);卫生发展专项资金研究项目(No.2014-2-4012);北京自然科学基金(No.L172055,No.7192158);中央高校基本科研基金(No.3332018032);国家万人计划。 |
| 摘 要： | 肝内胆管癌(ICC)可切除率低,进展期ICC的治疗有效率不高,预后很差。转化治疗在多种晚期肿瘤中有一定的疗效,是目前晚期肿瘤治疗的研究热点。随着对ICC基因组的深入了解和新的治疗药物的开发及组合,基于系统化疗的联合治疗策略,精准靶向治疗,免疫检查点抑制剂等显示出较好的疗效,使得部分进展期ICC病人能降期转化手术,获得长期生存。 |
| 关 键 词： | 肝内胆管癌 转化治疗 系统化疗 靶向治疗 免疫检查点抑制剂 |
Conversion therapy of advanced intrahepatic cholangiocarcinoma |
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| ZHAO Hai-tao,YANG Xu. Conversion therapy of advanced intrahepatic cholangiocarcinoma[J]. Chinese Journal of Practical Surgery, 2020, 40(6): 732-737. DOI: 10.19538/j.cjps.issn1005-2208.2020.06.23 | |
| Authors: | ZHAO Hai-tao YANG Xu |
| Affiliation: | (Department of Liver Surgery,Peking Union Medical College Hospital,Beijing 100630,China) |
| Abstract: | Conversion therapy of advanced intrahepatic cholangiocarcinoma ZHAO Hai-tao, YANG Xu. Department of Liver Surgery，Peking Union Medical College Hospital，Beijing 100630，China Corresponding author： ZHAO Hai-tao, E-mail：zhaoht@ pumch.cn Abstract Intrahepatic cholangiocarcinoma (ICC) has a low resectable rate. The effect of treatment and the prognosis are poor in advanced ICC. Conversion therapy shows a certain effect in the advanced tumors. With the understanding of the ICC genome and the development of new therapeutic drugs, combined strategies based on systemic chemotherapy, biomarker-driven targeted therapy and immune checkpoint inhibitors have shown promising efficacy. As a result, some advanced ICC patients have gotten experienced downstaging and undergone conversion therapy to achieve long-term survival. |
| Keywords: | intrahepatic cholangiocarcinoma conversion therapy systemic chemotherapy targeted therapy immune checkpoint inhibitors |
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