| 伏立康唑个体化给药研究进展 |
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| 引用本文： | 王晓晨,王思箭,刘林夕,刘其风,邹东娜.伏立康唑个体化给药研究进展[J].中国抗生素杂志,2020,45(1):16-25. |
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| 作者姓名： | 王晓晨 王思箭 刘林夕 刘其风 邹东娜 |
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| 作者单位： | 枣庄矿业集团中心医院;东营胜利胜采医院;山东大学附属省立医院 |
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| 基金项目： | 山东省药学会临床药学奥赛中青年科研资助项目(No.Sdpa-ask-2011-01) |
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| 摘 要： | 伏立康唑是目前临床用于治疗一些真菌感染的首选药物，其药动学复杂多变且受多种因素的影响。本文阐述了影响伏立康唑代谢的重要因素，包括药物相互作用、CYP2C19的基因多态性、炎症状态；总结了各国指南中对伏立康唑TDM指征、有效浓度范围、剂量调整等方面的推荐；并对不同人群中伏立康唑应用的研究进行了探讨。本文旨在推进伏立康唑个体化给药。
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| 关 键 词： | 伏立康唑 药动学 TDM 血药浓度 个体化 |
Advances in individualized administration of voriconazole |
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| Wang Xiao-chen,Wang Si-jian,Liu Lin-xi,Liu Qi-feng,Zou Dong-na.Advances in individualized administration of voriconazole[J].Chinese Journal of Antibiotics,2020,45(1):16-25. |
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| Authors: | Wang Xiao-chen Wang Si-jian Liu Lin-xi Liu Qi-feng Zou Dong-na |
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| Institution: | (Central Hospital of Zaozhuang Mining Group,Zaozhuang 277000;Dongying Shengli Shengcai Hospital,Dongying 257051;Shandong Provincial Hospital affiliated to Shandong University,Ji'nan 250000) |
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| Abstract: | In clinical, voriconazole is the first choice for the treatment of some fungal infections, and its pharmacokinetics is complex and variable and affected by many factors. In this paper, important factors affecting the metabolism of voriconazole, including drug drug interactions, gene polymorphism of CYP2C19 and inflammatory state, were described. The recommendations on the indications of TDM, effective concentration range, and dose adjustment of voriconazole in different guidelines were summarized. The application of voriconazole in different populations was also discussed. This paper aims to promote individualized administration of |
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| Keywords: | Voriconazole Pharmacokinetics TDM Blood drug concentration Individualization |
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