乳糖不耐受与钙摄取和骨健康研究进展

乳糖不耐受被认为与钙摄取和骨健康息息相关。目前普遍认为乳糖不耐受会降低钙摄入量,但对于钙吸收率的影响至今仍有较大的争议。在乳糖不耐受人群中,乳糖可能是影响钙吸收的重要因素,而早期研究设计中的不同乳糖剂量负荷也可能是导致不同结果的原因。而近十几年的研究发现乳糖酶相关基因类型是影响钙摄入与骨健康的重要因子。然而既往研究受限于知识技术的限制,研究内与研究间的异质性过大,这导致了相关研究出现相互矛盾的数据聚集。这也迫使当下进行更可靠的大样本对照研究来探讨乳糖不耐受与钙摄取和骨健康的相关性。

Correlations among lactose intolerance,calcium intake and bone health

Lactose intolerance is considered to be concerned with calcium intake and bone health.It is generally believed that lactose intolerance can reduce calcium intake,but its effect on calcium absorption rate is still controversial.Lactose appears to be an important factor of calcium absorption among lactose intolerant populations,and different doses of lactose in earlier study designs may also be responsible for different results.In recent decades,lactase related gene types have been found to be an important factor affecting calcium intake and bone health.However,being limited by knowledge and technology,the heterogeneity among previous studies is large,which contributes to the contradictory data aggregation in related studies.So more reliable and larger samples of control studies are warranted in order to explore the correlation among lactose intolerance,calcium intake and bone health.