中药对结核病免疫调控机制的研究进展

结核病的发病和转归与宿主的免疫状态、结核分枝杆菌的生长和抑制密切相关。研究表明,黄芩苷、虎耳草糖苷D、大黄提取物、异甘草素、黄芪多糖等诸多中药成分或中药提取物可通过诱导巨噬细胞自噬、加强结核病患者的免疫功能、抑制或破坏结核分枝杆菌的生成等不同途径起到辅助抗结核治疗的作用。作者对不同中药小分子化学物质对结核病的免疫调控机制进行综述,为中药辅助治疗结核病提供理论依据。

Research progress of immune regulatory mechanism of traditional Chinese medicine on tuberculosis

The pathogenesis and prognosis of tuberculosis are closely related to the host’s immune status and the growth or inhibition of Mycobacterium tuberculosis. The research has shown that many traditional Chinese medicine ingredients or extracts, such as baicalin, saxifragifolin D, rhubarb extract, isoliquiritigenin, and astragalus polysaccharide, can play an adjuvant anti-tuberculosis role by inducing macrophage autophagy, strengthening the immune function of tuberculosis patients, inhibiting or destroying the production of Mycobacterium tuberculosis and other different ways. In this paper, the immune regulation mechanism of different small molecular chemicals of traditional Chinese medicine on tuberculosis was reviewed, which provided theoretical basis for the treatment of tuberculosis with traditional Chinese medicine.