| 瑞德西韦(remdesivir)抗冠状病毒应用前景 |
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| 引用本文： | 王媛,周燕子,朱云颖,肖婷婷,黄晨,杨凯,叶静,吴珍珠,肖永红.瑞德西韦(remdesivir)抗冠状病毒应用前景[J].中国抗生素杂志,2020,45(2):103-112. |
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| 作者姓名： | 王媛 周燕子 朱云颖 肖婷婷 黄晨 杨凯 叶静 吴珍珠 肖永红 |
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| 作者单位： | 浙江大学医学院附属第一医院;宁波市医疗中心李惠利医院呼吸与危重症医学科;温州医科大学附属第二医院育英儿童医院传染内科 |
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| 基金项目： | 国家重点研发计划(No.2017YFC200203);浙江省重点研发计划(No.2015C03032)。 |
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| 摘 要： | 瑞德西韦是腺苷类似的氨基磷酸酯前体药，RNA依赖性的RNA聚合酶(RNA-dependent RNA-polymerases，RdRp)抑制剂，在细胞试验和动物试验中，它对RNA病毒(如MERS和SARS)具有广谱抗病毒活性，且毒性低。作为治疗2019新型冠状病毒(2019 novel coronavirus，2019-nCoV)感染的潜在药物，目前已在中国开展III期临床试验。本文就该药物抗病毒机制、体外抗病毒活性、动物实验、毒理实验、药动学和已进行的临床研究情况等进行全面综述，供临床参考。
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| 关 键 词： | 2019新型冠状病毒 瑞德西韦 |
Remdesivir prospect of anti-coronavirus effect |
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| Wang Yuan,Zhou Yan-zi,Zhu Yun-ying,Xiao Ting-ting,Huang Chen,Yang Kai,Ye-Jing,Wu Zhen-zhu,Xiao Yong-hong.Remdesivir prospect of anti-coronavirus effect[J].Chinese Journal of Antibiotics,2020,45(2):103-112. |
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| Authors: | Wang Yuan Zhou Yan-zi Zhu Yun-ying Xiao Ting-ting Huang Chen Yang Kai Ye-Jing Wu Zhen-zhu Xiao Yong-hong |
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| Institution: | (State Key Laboratory for Diagnosis and Treatment of Infectious Disease,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,Zhejiang University,Hangzhou 310003;Department of Pulmonary and Critical Care Medicine,Lihuili Hospital,Ningbo Medical Center,Ningbo 315041;Department of Infectious Diseases,the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou 325027) |
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| Abstract: | Remdesivir is a phosphoramidate prodrug of an adenine derivative, an RNA-dependent RNA-polymerases (RdRp) inhibitor. Remdesivir has broad-spectrum activities against RNA viruses such as MERS and SARS virus in cell cultures and animal models. As a potential drug for the treatment of 2019 novel coronavirus(2019-nCoV) infections, two phase III trials were initiated in early February this year to evaluate the efficacy and safety after intravenous administration in patients infected with 2019-nCoV. This review will focus on the antiviral mechanism, in vitro antiviral activity, animal experiments, toxicology, pharmacokinetics, and clinical studies of remdesivir to help clinicians gain a better understanding to the |
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| Keywords: | 2019 novel coronavirus Remdesivir |
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