巨噬细胞的抗结核纳米递药系统的应用进展

结核分枝杆菌作为一种巨噬细胞胞内寄生菌,传统药物治疗存在治疗周期长、生物利用度低、毒性大甚至耐药性增加等局限性问题。抗结核纳米递药系统作为一种抗结核新剂型,可将经济廉价的药物通过主动或被动方式递送到巨噬细胞内,以杀死正在复制或潜伏期的结核分枝杆菌。在此框架下,笔者探讨了抗结核纳米递药系统对巨噬细胞主被动靶向机制,及用于组装纳米递药系统的先进材料。此外,总结了影响靶向递送效率的因素及面临的挑战。

Advances in the application of anti-tuberculosis nanoscale drug delivery system targeting macrophages

Mycobacterium tuberculosis (MTB) is a facultative intracellular parasite of macrophages, traditional anti-TB therapy have limitations such as long course of treatment, low bio-availability, high systemic toxicity and even may induce drug resistance. As a new method of anti-tuberculous drug administration, the nanoscale drug delivery system can deliver low-cost drugs into macrophages actively or passively to inhibit the replicate or latent MTB. This review explores the active and passive targeting mechanism of anti-tuberculosis nanoscale drug delivery system to macrophages, and advanced materials for assembling nanoscale delivery system. In addition, factors affecting targeted delivery efficiency and challenges are summarized.