血清生物标志物与脑小血管病关系研究进展

目前认为脑小血管病（cerebral small vessel disease，CSVD）的主要机制是血管内皮损伤，而炎症和血管内皮损伤密切相关，血清中血管内皮损伤相关标志物及炎性标志物是反映炎症损伤血管内皮最直接、最简便的方法。关于生物标志物的研究为更深入了解CSVD的发生发展机制提供了重要的途径。目前多项研究表明炎性及血管内皮损伤相关标志物与CSVD的发生、发展关系密切。另外炎症与CSVD关系也可能受到人种、遗传等因素的影响。本文就血清中血管内皮相关标志物、炎性标志物与CSVD不同影像学标志的相关性研究进展进行综述。

Progress of Relationship between Serum Biomarkers and Cerebral Small Vessel Disease

It is currently believed that the main mechanism of cerebral small vessel disease
(CSVD) is vascular endothelial injury, which is closely related to inflammation. Serum endothelial
injury and inflammatory biomarkers are the most direct and simple methods to reflect endothelial
injury. Studies on biomarkers will help us to further understand the pathogenesis of CSVD. Many
studies have shown that inflammatory and endothelial injury biomarkers are closely related to the
occurrence and development of CSVD. In addition, the relationship between inflammation and
CSVD may be affected by race, genetics, and etc. This article reviewed the progress of relationship
between serum vascular endothelial injury markers, inflammatory markers and different imaging
markers of CSVD.