上清片联合西药治疗急性喉炎风热犯肺证临床研究

目的:观察上清片联合西药治疗急性喉炎风热犯肺证的临床疗效.方法:将106例急性喉炎风热犯肺证患儿随机分为对照组和观察组各53例.2组患儿均予头孢克肟颗粒、吸入用布地奈德混悬液治疗,并给予补液、退热、镇静等对症处理,观察组加服上清片,2组疗程均为7d.记录声音嘶哑和咽喉痛完全消失时间;治疗前、治疗7d评价主要症状、体征评...

Clinical Study on Shangqing Tablets Combined with Western Medicine for AcuteLaryngitis with Wind Heat Invading the Lung Syndrome

Objective:To observe the clinical effect of Shangqing tablets combined with western medicine on acute laryngitis with wind heat invading the lung syndrome.Methods:A total of 106 children with acute laryngitis with wind heat invading the lung syndrome were randomly divided into the control group and the observation group,53 cases in each group.Both groups were treated with cefixime granules and budesonide suspension for inhalation,and symptomatic treatment such as rehydration,antipyretic and sedation;the observation group was additionally given Shangqing tablets.Both groups were treated for seven days.Before treatment and seven days after treatment,the scores of main symptoms and signs were evaluated;the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),blood routine test,electrocardiogram,liver function and kidney function were detected,and the adverse reactions during the treatment were recorded.Results:After treatment,the clinical effect in the observation group was better than that in the control group(P<0.05).The disappearance time of hoarseness and sore throat in the observation group was faster than that in the control group(P<0.01).The scores of hoarseness,sore throat,vocal cord condition and laryngeal mucosa in both groups were decreased when compared with those before treatment(P<0.01),and the above four scores in the observation group were lower than those in the control group(P<0.01).The levels of CRP and TNF-αin the two groups were decreased when compared with those before treatment(P<0.01),and the above two levels in the observation group were lower than those in the control group(P<0.01).There was no obvious drug-related adverse events in both groups.Conclusion:The additional application of Shangqing tablets based on western medicine for children with acute laryngitis with wind heat invading the lung syndrome,can effectively reduce hoarseness,sore throat and other symptoms,shorten the course of disease and control inflammatory reaction,with great safety.