不同不育类型患者精液质量比较及对补救卵胞浆内单精子注射术临床结局的影响分析

目的 探讨不同不育类型患者精液质量情况及其对补救卵胞浆内单精子注射术(R-ICSI)临床结局的影响.方法 回顾性研究2014-01～2018-12于广西壮族自治区人民医院生殖医学与遗传中心行常规体外受精-胚胎移植(IVF-ET)失败而进行R-ICSI治疗的98对不孕不育夫妇的临床资料.根据不育类型将98对夫妇分为原发性...

Comparison of semen qualities in patients with different types of infertility and their effects on clinical outcomes of rescue intracytoplasmic sperm injection

Objective To investigate the semen qualities of the patients with different types of infertility and their effects on the clinical outcomes of rescue intracytoplasmic sperm injection(R-ICSI).Methods The clinical data of 98 infertile couples who failed in routine in vitro fertilization and embryo transfer(IVF-ET)and received R-ICSI treatment in the Center for Reproductive Medicine and Genetics,the People′s Hospital of Guangxi Zhuang Autonomous Region from January 2014 to December 2018 were retrospectively analyzed.According to the types of infertility,the 98 couples were divided into primary infertility group(n=56)and secondary infertility group(n=42).The general conditions,semen quality,embryo development and clinical outcomes were compared between the two groups.Results The sperm progressive motility in the secondary infertility group was higher than that in the primary infertility group,and the sperm DNA fragmentation index(DFI)in the secondary infertility group was lower than that in the primary infertility group,and the differences were statistically significant between the two groups(P<0.05).However,there were no significant differences between the two groups in terms of semen volume,sperm concentration,total number of sperm,normal sperm morphology rate,sperm acrosome integrity rate and sperm spontaneous acrosome reaction rate(P>0.05).There were no significant differences in the fertilization rate,cleavage rate,excellent embryo rate,live birth rate,premature birth rate,abortion rate,single birth rate and twin birth rate between the two groups(P>0.05).There was significant difference in the clinical pregnancy rate between the two groups(P<0.05).Conclusion The semen quality of primary infertility patients is poor,and their clinical pregnancy rate is low.The types of infertility should be taken into consideration in diagnosis and treatment of reproductive assisted pregnancy.