当今慢性乙型肝炎治疗实践对HBV核酸检测方法的新需求

乙型肝炎病毒感染引起的慢性乙型肝炎仍是威胁我国人民生命健康的重要问题.当前治疗慢性乙型肝炎以口服恩替卡韦、替诺福韦和丙酚替诺福韦等高耐药屏障的一线核苷(酸)类似物为主,可强效抑制病毒复制,减少肝硬化和肝细胞癌的发生率.然而当前临床实践中,在启动治疗、监测疗效及判定停药等方面,均存在一定困难或争议.实现慢性乙型肝炎的"精...

New requirements for hepatitis B virus nucleic acid testing in current clinical practice of chronic hepatitis B treatment

Chronic hepatitis B(CHB)caused by hepatitis B virus(HBV)infection remains a major public health issue for the Chinese people.The current treatment regimen for CHB is mainly based on the oral administration of the first-line nucleos(t)ide analogs such as entecavir,tenofovir,and propofol tenofovir.These nucleos(t)ide analogs constitute a high drug-resistance barrier,strongly inhibit viral replication,and significantly reduce the incidence of liver cirrhosis and hepatocellular carcinoma.However,there are some difficulties or controversies in starting treatment,monitoring efficacy and determining drug withdrawal in current clinical practice.The realization of precision treatment of CHB largely depends on the sensitive and specific nucleic acid testing technology of HBV and the scientific interpretation of its results.