支气管肺发育不良的预防和治疗

支气管肺发育不良(BPD)是导致新生儿死亡的重要原因之一,也是早产儿常见的慢性肺疾病。自1967年首次报道以来,五十余年中仍缺乏有效的治疗方法。高浓度氧、气压伤、容积伤和感染是导致早产儿发育不成熟肺损伤的重要原因,产前激素的应用及抗感染有利于降低早产的发生,早产儿生后积极的营养支持、限制液体入量及采用保护性通气策略有利于减轻肺损伤,一氧化氮吸入治疗对支气管肺发育不良的作用研究尚不一致,目前认为维生素A和咖啡因具有预防和治疗支气管肺发育不良的作用,间充质干细胞正在探索用于支气管肺发育不良的治疗。

Progress on the prevention and treatment of bronchopulmonary dysplasia

Bronchopulmonary dysplasia(BPD) is one of the important causes for of neonatal death and a common chronic lung disease in premature infants.Since first reported in 1967, there is still no effective treatment over the past 50 years.High concentration of oxygen, barotrauma, volumetric injury and infection are the important causes for immature lung injury in premature infants.The application of prenatal hormones and anti-infection are helpful to reduce the incidence of premature birth.Positive nutritional support and protective ventilation strategy are beneficial to reduce lung injury.However, the current research Results on the effect of nitric oxide inhalation therapy on BPD are still inconsistent.It is believed that vitamin A and caffeine can prevent and treat BPD, and mesenchymal stem cells are currently being explored on the treatment of BPD.