山东省丁型肝炎病毒感染调查研究

为了解山东省丁型肝炎病毒感染状况 ,并探讨丁型肝炎病毒 ( HDV)感染与乙型肝炎病毒 ( HBV)感染的关系 ,应用酶联免疫吸附试验 ( EL ISA)对山东省 2 681例乙型肝炎病毒感染者进行了血清丁型肝炎病毒抗体 (抗 - HDV)检测 ,共检出抗 - HDV阳性者 2 0 7例 ,阳性率 7.72 %。HBs Ag携带者组抗 - HDV阳性率 3.16% ,乙肝患者组抗 - HDV阳性率 13.15% ,两组之间的差异有非常显著性 ( P<0 .0 0 1)。在乙肝患者组中 ,慢性活动性肝炎患者和重症肝炎患者抗 - HDV阳性率高于急性肝炎患者和慢性迁延性肝炎患者 ,差异有非常显著性 ( P<0 .0 0 1) ,表明乙肝病史越长、病情越重 ,其抗 - HDV阳性率越高。提示乙肝患者联合或重叠感染 HDV与乙肝慢性化和病情加重的形成有关。

Study of HDV Infection in Shandong Province (1994-1997)

To understand the situation of HDV infection in Shandong province and to explore the relationship between HDV and HBV infections,2 681samples infected with HBV were tested for serum anti- HDV with enzyme linked immunosorbent assay,in Shandong.Among them,2 0 7 ( 7.72 % ) were found to be anti- HDV positive.Anti- HDV positive rates in HBs Ag carriers and in hepatitis B patients were3.16% and13.15% ,respectively.A significant difference( P<0 .0 0 1) was noticed between the two groups.In the second group,anti- HDV positive rates in patients with chronic active hepatitis and severe hepatitis were both higher than those in patients with acute hepatitis and chronic persistent hepatitis and the difference was significant( P<0 .0 0 1) .The longer the history and the more severe the condition the higher of the anti- HDV positive rate was seen. The results indicated that the combined and over- lapping HDV infections were both responsible for the chronic status of hepatitis B and its deterioration.