| MicroRNAs在视网膜母细胞瘤的研究新进展 |
| |
| 引用本文： | 曾静,唐瑞雪,何融泉,陈罡. MicroRNAs在视网膜母细胞瘤的研究新进展[J]. 国际眼科杂志, 2014, 14(11): 1995-1998 |
| |
| 作者姓名： | 曾静 唐瑞雪 何融泉 陈罡 |
| |
| 作者单位： | 广西医科大学第一附属医院眼科, 中国广西壮族自治区南宁市,530021 |
| |
| 基金项目： | 广西壮族自治区卫生厅科研课题(No.Z2008159) |
| |
| 摘 要： | 细胞中的非编码单链小分子RNA,通过对mRNA的降解和翻译抑制调控基因表达。 MicroRNAs作为癌基因或抑癌基因,可直接参与RB的发生、发展,并在RB的早期诊断和临床靶向治疗中具有重要作用。本文主要对近年来RB中microRNAs的表达情况以及其在RB形成中的作用机制的研究进行简要综述。
|
| 关 键 词： | microRNAs 视网膜母细胞瘤 癌基因 抑癌基因 |
| 收稿时间： | 2014-05-05 |
| 修稿时间： | 2014-10-27 |
New research progress of microRNAs in retinoblastoma |
| |
| Jing Zeng,Rui-Xue Tang,Rong-Quan He and Gang Chen. New research progress of microRNAs in retinoblastoma[J]. International Eye Science, 2014, 14(11): 1995-1998 |
| |
| Authors: | Jing Zeng Rui-Xue Tang Rong-Quan He Gang Chen |
| |
| Affiliation: | Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China;Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China;Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China;Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China |
| |
| Abstract: | Retinoblastoma(RB)is the most common intraocular malignancy of children with extremely poor prognosis. MicroRNAs are small non-coding single-stranded RNAs in eukaryotic cells, which regulate the expression of gene by mRNA degradation or translation inhibition. MicroRNAs, acting as oncogenes or tumor suppressor genes, are associated with the occurrence and development of RB directly, which is vital for the early diagnosis and clinical targeted therapy of RB. This review summarized the expression of microRNAs in RB and the related mechanism. |
| |
| Keywords: | microRNAs retinoblastoma oncogenes tumor suppressor gene |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《国际眼科杂志》浏览原始摘要信息 |
|
点击此处可从《国际眼科杂志》下载全文 |
|
