Œdème cérébral : nouvelles pistes thérapeutiques |
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Authors: | H Quintard C Ichai |
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Institution: | Service de réanimation médicochirurgicale, hôpital Saint-Roch, CHU de Nice, université de médecine de Nice Sophia-Antipolis, 5, rue Pierre-Dévoluy, 06006 Nice cedex 1, France |
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Abstract: | Cerebral oedema (CO) after brain injury can occur from different ways. The vasogenic and cytotoxic oedema are usually described but osmotic and hydrostatic CO, respectively secondary to plasmatic hypotonia or increase in blood pressure, can also be encountered. Addition of these several mechanisms can worsen injuries. Consequences are major, leading quickly to death secondary to intracerebral hypertension and later to neuropsychic sequelae. So therapeutic care to control this phenomenon is essential and osmotherapy is actually the only way. A better understanding of physiopathological disorders, particularly energetic ways (lactate), aquaporine function, inflammation lead to new therapeutic hopes. The promising experimental results need now to be confirmed by clinical data. |
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Keywords: | Agression cé ré brale &OElig dè me cé ré bral Thé rapie osmotique |
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