| 前列腺素E1在心肺转流中的心肌保护作用 |
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| 引用本文： | 张浩,陈亮,甄福喜.前列腺素E1在心肺转流中的心肌保护作用[J].江苏医药,2006,32(5):439-441. |
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| 作者姓名： | 张浩 陈亮 甄福喜 |
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| 作者单位： | 210029,南京医科大学第一附属医院胸心外科 |
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| 摘 要： | 目的研究前列腺素E1（PGE1）在心肺转流（CPB）中的心肌保护作用，并探讨其可能机制。方法选取2005年5月至9月心内直视手术病人30例，随机等分为观察组和对照组，观察组应用PGE1；选取CPB前后不同时间点测定血中肌酸激酶同功酶（CK-MB）、肌钙蛋白Ⅰ（cTnⅠ）；分析组间、组内各项指标变化。结果CPB后测得观察组不同时间点CK-MB及cTnⅠ测量值均显著低于对照组（P〈0．05）。结论PGE1通过稳定生物膜、抑制血中性粒细胞活性、减轻脂质过氧化反应，防止缺血一再灌注损伤等，产生明显的CPB后炎症反应的抑制作用，在CPB中发挥一定的心肌保护作用。
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| 关 键 词： | 前列腺素E1 心肺转流 心肌保护 |
| 收稿时间： | 2005-12-06 |
| 修稿时间： | 2005年12月6日 |
Protective effect of prostaglandin E1 on myocardium during cardiopulmonary bypass |
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| ZHANG Hao,CHEN Liang,ZHEN Fuxi.Protective effect of prostaglandin E1 on myocardium during cardiopulmonary bypass[J].Jiangsu Medical Journal,2006,32(5):439-441. |
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| Authors: | ZHANG Hao CHEN Liang ZHEN Fuxi |
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| Institution: | Department of Cardiothoracic Surgery, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, CHINA |
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| Abstract: | Objective To study the protective effect of prostaglandin E_1(PGE_1) on myocardium during cardiopulmonary bypass(CPB) and explore the possible mechanism of PGE_1. Methods Thirty inpatients undergoing open heart surgery were randomly divided into testing group and control group. The PGE_1 was applicated in testing group. The CK-MB and cTnI were detected in two groups at various time points during CPB. The possible mechanism of PGE_1 was analyzed. Results The values of CK-MB and cTnI in testing group after CPB were significantly lower than those in control group at different time points (P<0.05). Conclusion PGE_1 can prevent the myocardium from ischemia reperfusion injury possibly by stabilizing the biomembrane, suppressing the activity of neutrophilic granulocyte and relieving the lipid peroxidation. |
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| Keywords: | Prostaglandinn E1 Cardiopulmonary bypass Myocardial protection |
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