丹参、辅酶Q10对低氧供豚鼠动脉血气及耳蜗电图的影响

目的 探讨凡参，畏酶Ｑ１０及联合用药的抗缺氧作用。方法 豚鼠低氧供模型（５％Ｏ２＋９５％Ｎ２）以上，比较对照组、丹参组、畏酶Ｑ１０组及联合用药组低氧３０ｍｉｎ后动脉血气及耳蜗电图的变化。结果 低氧３０ｍｉｎ时辅酶Ｑ１０组及联合用药组Ｏ２ｃｏｎｔ，Ｏ２ｓａｔ及ｐＨ显著高于对照且及丹参组（Ｐ〈０．０５）。后两组间差异无显著性（Ｐ〉０．０５）；各用药组耳蜗电图Ｎ１阈移及振幅下降幅度均显著低于对照组（Ｐ〈

Effects of salvia miltiorrhizae combined with coenzyme Q10 on artery blood and electrocochleogram of the hypoxic guinea pig

Objective To explore the anti-hypoxia function of salvia miltiorrihizae combined with CoQ 10 . Methods In the guinea pig hypoxic model (5 % O 2 95 % N 2 ), changes of the artery blood gas and electrocochleogram during hypoxia were compared between control group,salvia miltiorrihizae group, CoQ 10 group and salvia miltiorrihizae combined with CoQ 10 group after 30 minutes. Results At the end of hypoxia, O 2 cont, O 2 sat and pH of CoQ 10 group and salvia miltiorrihizae CoQ 10 group showed higher than control group and salvia miltiorrihizae group (P<0.01), but the difference between the latter two groups was not significant (P>0.05).The changes of N 1 threshold and amplitude of each drug group were less than control group (P<0.01), and those of the salvia miltiorrihizae combined with CoQ 10 group were less than other groups with drugs only (P<0.05). Conclusion Salvia mitiorrihizae combined with CoQ 10 can effectively protect cochlear function from hypoxia injury.