| 缩泉丸对自然衰老大鼠逼尿肌AC-cAMP通路的影响 |
| |
| 引用本文： | 吴清和,吴君,黄萍,操红缨,邝兆进.缩泉丸对自然衰老大鼠逼尿肌AC-cAMP通路的影响[J].广州中医药大学学报,2011(5):512-515. |
| |
| 作者姓名： | 吴清和 吴君 黄萍 操红缨 邝兆进 |
| |
| 作者单位： | 广州中医药大学中药学院,广东广州,510006 |
| |
| 基金项目： | 国家自然科学基金资助项目(编号:30873425) |
| |
| 摘 要： | 目的]观察自然衰老大鼠膀胱逼尿肌中腺苷酸环化酶(AC)、环磷酸腺苷(cAMP)及蛋白激酶A(PKA)的浓度变化及PKA蛋白表达,探讨缩泉丸“缩尿”的作用机理.方法]选用老年大鼠(20月龄)50只,分为模型组,金匮肾气丸组,缩泉丸高、中、低剂量组,每组10只;青年大鼠(3月龄)10只作为空白组.采用酶联免疫吸附( E...
|
| 关 键 词： | 多尿/中药疗法 缩泉丸/药理学 蛋白表达 疾病模型 动物 大鼠 |
Effects of Suoquan Pills on AC-cAMP Pathway in the Detrusor of Natural Aging Rats |
| |
| WU Qinghe,WU Jun,HUANG Ping,CAO Hongying,KUANG Zhaojin.Effects of Suoquan Pills on AC-cAMP Pathway in the Detrusor of Natural Aging Rats[J].Journal of Guangzhou University of Traditional Chinese Medicine,2011(5):512-515. |
| |
| Authors: | WU Qinghe WU Jun HUANG Ping CAO Hongying KUANG Zhaojin |
| |
| Institution: | WU Qinghe,WU Jun,HUANG Ping,CAO Hongying,KUANG Zhaojin (School of Chinese Herbal Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China) |
| |
| Abstract: | Objective The mechanism of Suoquan Pills(SP) in reducing urination was investigated by observing the concentration of adenylate cyclase(AC),cyclic adenosine monophosphate(cAMP)and protein kinase(PKA) and the expression of PKA protein in the natural aging rat bladder detrusor.Methods Fifty senile rats(20 months old) were equally randomized into five groups: model group,Jinkui Shenqi Pills group,and high-,middle and low-dose SP groups.And 10 young rats(3 months old) were chosen as control.The contents of AC,c... |
| |
| Keywords: | POLYURIA/TCD therapy SUOQUAN PILLS/pharmacology PROTEIN EXPRESSION DISEASE MODELS ANIMAL RATS |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
