利培酮对阴性精神分裂症认知损害的影响研究

目的 了解利培酮治疗对阴性精神分裂症病人认知功能的影响及阴性症状改善与认知功能的关系。方法 对阴性精神分裂症患者利培酮治疗前后进行阴性症状评定量表（SANS）、简明精神病评定量表（BPRS）评定精神症状；用Wisconsin卡片分类测验（WCST），Wechsler记忆测验（WMS）、Wechsler成人智力量表（WAIS-RC）评定认知功能。结果 利培酮组能改善精神症状、记忆、执行功能，SANS因子分的减分与WMS中理解、背数量表分和WCST分的进步相关。结论 利培酮对阴性精神分裂症病人的精神症状和部分认知损害有改善，阴性症状的改善与认知功能的提高有明显相关性。

A Study of Risperidone on Improvement of Cognitive Impairment in Negative Schizophrenia

Objective To explore the effect of risperidone on cognitive impairment in negative schizophrenia and the relationship of improvement of psychotic symptoms and cognitive impairment. Methods Negative symptoms, memory, attention, executive function were assessed with BPRS, SANS, WMS, WAIS-RC and WCST before and after treatment in patients taking risperidone. Results Risperidone can significantly improve psychotic symptoms, memory and executive function. There were a positive correlation between the descending of SANS factors scale and improvement of WMS and WCST. Conclusion Risperidone can improve the negative symptoms and part cognitive impairment of negative schizophrenia. The improvement of psychotic symptoms has marked correlation with enhancement of cognitive function.