病毒性肝炎患者血清IL-6和T细胞亚群的关系

采用ＭＴＴ比色法和抗体致敏的红细胞花环试验（间接法）　检测了９１例病毒性肝炎患者血清ＩＬ－６和Ｔ细胞亚群。　结果显示，病毒性肝炎患者血清ＩＬ－６活性均明显高于正常对照组（Ｐ＜０．０１），以重型肝炎为最高；且与肝细胞损害程度呈正比（Ｐ＜０．０１）；ＣＤ４~＋细胞、ＣＤ４＋／ＣＤ８~＋均明显降低，与血清ＩＬ－６呈负相关；ＣＯ８~＋细胞明显增高，与血清ＩＬ－６呈正相关（Ｐ＜０．０１）。表明，血清ＩＬ－６与机体细胞免疫功能密切相关，二者互为因果，共同参与病毒性肝炎的免疫病理损害，可作为判断病情和预后及免疫调节治疗的监测指标。

The relation of interleukin 6 and T cell subsets in viral hepatitis

Serum level of interleukin 6 (IL - 6 ) and T lymphocyte subtype were determined in 91 viral hepatitis patients with MTT colormetric assay and erythrocyte garland test, In comparison with NC , IL-6 serum level were significantly elevated in patients with viral hepatitis (P <0.01) . The levels in patients with severe hepatitis (SH ) were highest in all patients detected (P < 0.01 ). The levels in patients with acute hepatitis (AH ) , chronic active hepatitis (CAH ) and post hepatitis cirrhosis (HC ) were significantly in- creased in comparison with chronic persistent hepatitis (CPH ). The patients with more than 160U ALT and 34. 2umol/L SB showed higher IL-6 level than NC (P<0. 0l ). There was a close correlation between serum IL-6 and T lymphocyte subtype. The results suggest that serum level of IL-6 is closely related to the degree of hepatocyte damage , cellular immunity. Higher level of IL-6 involves the immunopathogenesis of viral hepatitis by its biological function , Therefore , the enhancement of serum IL - 6 may be an important marker of the activity of liver pathological changes.