| HLA-DQA1、DQB1、DRB1 02,07,09等位基因及单倍型在华东地区汉族人群的分布 |
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| 引用本文： | 张卫华,沈福民,孟炜,江峰.HLA-DQA1、DQB1、DRB1 02,07,09等位基因及单倍型在华东地区汉族人群的分布[J].中国免疫学杂志,1998(2). |
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| 作者姓名： | 张卫华 沈福民 孟炜 江峰 |
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| 作者单位： | 上海医科大学流行病学教研室 |
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| 基金项目： | 国中华医学基金会CMB基金 |
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| 摘 要： | 应用ＰＣＲ－ＳＳＯ方法，对华东地区汉族人群进行了ＨＬＡ－ＤＱＡ１、－ＤＱＢ１和ＤＲＢ１＊０２，０７，０９基因分型。ＤＱＡ１中以ＤＱＡ１＊０３０１基因频率最高（０．３８４４），其次为＊０５０１（０．１４０６）和０１０２（０．１２１９），＊０４０１最低（０．０２８１）；ＤＱＢ１中以ＤＱＢ１＊０３０３基因频率最高（０．２３４２），其次为＊０３０１（０．１８９９）、＊０６０１（０．１２０３）和＊０２０１（０．１１０８），＊０５０１、＊０６０４和＊０６０５最低（均为０．０１２７）；ＤＲ９基因频率较高（０．２３１０），ＤＲ２中ＤＲＢ１＊１５０１占７３％，基因频率为０．０８５４，未见＊１６０１。ＤＱＡ１、ＤＱＢ１及ＤＲＢ１等位基因之间存在显著的连锁不平衡。ＤＲＢ１＊０９０１－ＤＱＡ１＊０３０１－ＤＱＢ１＊０３０３、ＤＱＡ１＊０１０３－ＤＱＢ１＊０６０１等为常见单倍型。本资料与我国其他汉族人群资料有可比性，也存在一定差异。
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| 关 键 词： | PCR-SSO HLA 汉族 |
DISTRIBUTION OF HLA DQA1,DQB1 AND DRB1*02,07,09 ALLELES AND HAPLOTYPES IN HAN NATIONALITY IN EAST CHINA |
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| Zhang Weihua,Shen Fumin,Meng Wei et al.DISTRIBUTION OF HLA DQA1,DQB1 AND DRB1*02,07,09 ALLELES AND HAPLOTYPES IN HAN NATIONALITY IN EAST CHINA[J].Chinese Journal of Immunology,1998(2). |
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| Authors: | Zhang Weihua Shen Fumin Meng Wei |
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| Institution: | Zhang Weihua,Shen Fumin,Meng Wei et al.Department of Epidemiology,Shanghai Medical University,Shanghai 200032 |
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| Abstract: | Using PCR SSO methods, the authors performed genotyping of HLA DQA1,DQB1, and DRB1*02,07,09 alleles in Han nationality in east China. DQA1*0301 gene frequency was the highest(0.384 4) among DQA1 alleles, followed by 0501(0.140 6) and 0102( 0.121 9 ), 0401 was the lowest(0.028 1). DQB1*0303 frequency was the highest( 0.234 2 ) among DQB1 alleles, followed by 0301(0.189 9), 0601(0.120 3) and 0201( 0.110 8 ), 0501, 0604 and 0605 were the lowest(0.012 7). DR9 frequency was also high( 0.231 0 ). DRB1*1501 composed the main subtype of DR2 alleles(73%) with gene frequency of 0.085 4 , 1601 was absent. DQA1,DQB1 and DRB1 loci showed significant linkage disequilibrium. DRB1*0901 DQA1*0301 DQB1*0303, DQA1*0103 DQB1*0601 et al. were common haplotypes. Data in this study was comparable with other studies in Chinese Han nationality but also show some differences. |
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| Keywords: | PCR SSO HLA Chinese Han nationality |
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