| 溶剂分散法改善小剂量难溶性药物的溶出均一性 |
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| 引用本文： | 金描真,李晓芳,洪慧.溶剂分散法改善小剂量难溶性药物的溶出均一性[J].广东药学院学报,2004,20(5):464-465,477. |
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| 作者姓名： | 金描真 李晓芳 洪慧 |
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| 作者单位： | 广东药学院,药剂学教研室,广东,广州,510240;广东药学院,药剂学教研室,广东,广州,510240;广东药学院,药剂学教研室,广东,广州,510240 |
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| 摘 要： | 目的 研究溶剂分散法改善小剂量难溶性药物的溶出均一性。方法 采用溶剂分散法制备含小剂量难溶性药物格列苯脲的复方盐酸二甲双胍胶囊，与采用格列苯脲微粉化法制备的胶囊进行溶出均一性比较。结果与结论 溶剂分散法制备的胶囊中格列本脲溶出均一性优于将格列苯脲微粉化制得的胶囊。
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| 关 键 词： | 格列苯脲 溶剂分散法 微粉化技术 溶出均一性 |
| 文章编号： | 1006-8783(2004)05-0464-02 |
Improvement in dissolution uniformity of medicament with low dose and solubility as solvent dispersing method |
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| JIN Miao-zhen,LI Xiao-fang,HONG Hui.Improvement in dissolution uniformity of medicament with low dose and solubility as solvent dispersing method[J].Academic Journal of Guangdong College of Pharmacy,2004,20(5):464-465,477. |
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| Authors: | JIN Miao-zhen LI Xiao-fang HONG Hui |
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| Abstract: | To compare the dissolution uniformity of glibenclamide in compound metformin hydrochloride capsules prepared with solvent dispersing method using microcrystallite as carrier to that prepared with micronization method. The result shows that the solvent dispersing method has an advantage over micronization method for dissolution uniformity of glibenclamide. |
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| Keywords: | glibenclamide solvent dispersing method dissolution uniformity micronization method |
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