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Galactocerebroside antiserum causes demyelination of cat optic nerve |
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| Authors: | W.M. Carroll A.R. Jennings F.L. Mastaglia |
| Affiliation: | aDepartment of Neurology and University Department of Medicine, Queen Elizabeth II Medical Centre, Nedlands, W.A., 6009 Australia |
| Abstract: | A model of immune-mediated optic nerve demyelination is described. Micro-injection of small volumes (< 5 μl) of high titer polyclonal anti-Gal-C serum into the cat optic nerve resulted in a focal, highly selective demyelinative lesion followed by remyelination. Demyelination appears to be due to a dual effect of myelin and on oligadendrocytes. The numbers of these cels within the lesion were initially reduced but subsequently increased as remyelination occured. |
| Keywords: | galactocerebroside antibodies demyelination remyelination optic nerve |
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