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目的探讨美罗培南在治疗机械通气新生儿下呼吸道细菌感染中的疗效。方法对应用机械通气的新生儿下呼吸道细菌感染患儿37例采用美罗培南静脉注射治疗,美洛培南治疗方法和剂量为20~30mg/kg,每日2次,静脉滴注。临床疗效评价分为痊愈、显效、进步和无效。痊愈和显效作为有效统计。结果除1例嗜麦芽窄食单胞菌对美罗培南耐药外,其余22例革兰阴性细菌均为敏感,达95·7%。在治疗结束时,痊愈19例,显效7例,进步2例,无效9例。总有效率为70·3%。无不良反应发生。结论美罗培南适用于机械通气的新生儿下呼吸道细菌感染,值得临床进一步研究。

Effect of meropenem on lower respiratory infection in newborn infants with mechanical ventilation

Objective To explore the effect of meropenem on lower respiratory infection in newborn infants with mechanical ventilation.Methods Thirty-seven mechanical ventilated newborn infants with lower respiratory infection were involved in this study.When the patients were treated with mechanical ventilation,they were administrated by venous injection of meropenem with a dose of 20~30mg/kg,twice a day.The evaluation of clinical effect was divided into four degrees: healing,remarkable effect,advancement,and invalidation.The degree of healing and remarkable effect was appraised as effective.Results At the end of the course with meropenem,19 newborns were healed,7 had remarkable effect,2 had advanced effect,and 9 had no effect.The total effect rate of meropenem reached 70.3%.No side effect was observed.Conclusion Meropenem is suitable for treating mechanical ventilated newborn infants with lower respiratory infection,and worth further investigating.