A tissue-engineered approach towards retinal repair: Scaffolds for cell transplantation to the subretinal space |
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| Authors: | Sara Royce Hynes Erin B. Lavik |
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| Affiliation: | (1) Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA;(2) Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA; |
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| Abstract: | Background Several mechanisms of retina degeneration result in the deterioration of the outer retina and can lead to blindness. Currently, with the exception of anti-angiogenic treatments for wet age-related macular degeneration, there are no treatments that can restore lost vision. There is evidence that photoreceptors and embryonic retinal tissue, transplanted to the subretinal space, can form new synapses with surviving host neurons. However, these transplants have yet to result in a clinical treatment for retinal degeneration. |
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