| 趋化因子及其受体与艾滋病的研究进展* |
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| 引用本文： | 王峰,孙晗笑. 趋化因子及其受体与艾滋病的研究进展*[J]. 中国新药杂志, 2007, 16(16): 1243-1246 |
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| 作者姓名： | 王峰 孙晗笑 |
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| 作者单位： | 暨南大学药学院基因组药物研究所,广州,510632 |
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| 基金项目： | 广东省医学科学技术研究基金 |
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| 摘 要： | HIV感染和艾滋病(AIDS)是严重危害人类健康的疾病,用抗HIV药物可以明显延缓AIDS进程降低死亡率。趋化因子是一系列结构相似的具有趋化功能的细胞因子。趋化因子受体CXCR4和CCR5是HIV感染重要的辅助受体,这一发现为进一步了解HIV感染机制和AIDS治疗提供了新的思路。现主要综述趋化因子及其受体的结构和功能,以及它们在抗HIV感染方面的作用。
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| 关 键 词： | 趋化因子 趋化因子受体 辅助受体 艾滋病 |
| 文章编号： | 1003-3734（2007）16-1243-04 |
| 收稿时间： | 2007-01-10 |
| 修稿时间： | 2007-01-10 |
Advances in chemokines and chemokine receptors about AIDS |
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| WANG Feng,SUN Han-xiao. Advances in chemokines and chemokine receptors about AIDS[J]. Chinese Journal of New Drugs, 2007, 16(16): 1243-1246 |
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| Authors: | WANG Feng SUN Han-xiao |
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| Affiliation: | Institute of Genomic Medicine ,College of Pharmacy, Jinan University, Guangzhou 510632, China |
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| Abstract: | The human immunodeficiency virus(HIV) is the primary cause of the acquired immunodeficiency syndrome(AIDS),which is being regarded as a threat to public health.Treatment with anti-HIV drugs dramatically slows the progress of the disease and has caused the number of AIDS deaths to plummet.Chemokines are a family of structurally related glycoproteins with potent chemotactic activity.CCR5 and CXCR4 are the two main co-receptors essential for HIV entry,which provide a new strategy for HIV treatment.This review summarizes the structure and function of chemokines and chemokine receptors,and their application in antiviral therapy. |
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| Keywords: | chemokines chemokine receptors co-receptors acquired immunodeficiency syndrome |
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