检测血清尿素水平评估慢性肝炎病情

目的检测慢性肝病患者血清尿素(Urea)水平的变化,探讨其在评估慢性肝炎病情中的意义。方法采用连续监测法测定186例(分5组)慢性肝病患者及40例正常人血清Urea水平,同时测定肝功能指标,进行比较分析。结果正常对照组血清Urea水平为5.01±0.68mmol/L,慢性肝炎轻度患者为4.90±0.76mmol/L、中度患者为4.14±0.81mmol/L、重度患者为4.09±0.69mmol/L。慢性肝炎中度及重度患者血清Urea水平明显低于正常对照组(t=4.635、3.819,P<0.01)和慢性肝炎轻度患者(t=2.818、2.093,P<0.01、P<0.05)。肝硬化代偿组患者Urea(4.88±1.24mmol/L)与正常对照组比较无显著性变化(t=0.559,P>0.05),但肝硬化失代偿组患者Urea水平(6.08±2.67mmol/L)明显高于正常对照组(t=2.446,P<0.05)。结论慢性肝炎患者血清Urea水平降低,且随着病情的加重呈进行性下降,血清Urea测定可作为慢性肝炎肝脏受损的一项指标,同时对慢性肝炎病情的估计有一定价值。

Detection of serum urea for assessing the extent of condition in chronic hepatitis

Objective To detect the level of serum urea and to study its application for assessing the extent of condition in patients with chronic hepatitis.Methods Serum urea levels of 186 patients with chronic hepatitis divided into 5 groups and of 40 normal subjects(as control)were measured by con-tinuous monitoring method, and the indexes of liver function were measured simultaneously. Above- abtained results were compared and analysed.Results Serum urea levels of normal controls were 5.01±0.68mmol/L, and those of mild group, moderate group and severe group in the patients with chronic hepatitis were 4.90±0.76mmol/L,4.14±0.81mmol/L and 4.09±0.69mmol/L respectively.Serum urea levels of moderate and severe groups were lower obviously than those of normal group(t=4.635?3.819,P<0.01) and those of mild group(t=2.818?2.093, P<0.01?P<0.05), and the difference were significant. No significant variation of serum urea(4.88±1.24mmol/L) was shown in hepatocirrhosis compensation group compared with that in normal controls(t=0.559,P>0.05).Serum urea levels(6.08±2.67mmol/L)of hepatocirrhosis decompensation group were higher obviously than those of normal controls and the difference between them was significant(t=2.446,P<0.05).Conclusion Serum urea levels decreased and decrease continuously along with the condition becoming more severe in the patients with chronic hepatitis. Serum urea is a useful index for assessing the extent of condition in the patients with chronic hepatitis.