Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation |
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Authors: | Patel G K Morris E Rashid M R Anstey A V |
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Institution: | Department of Dermatology, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, U.K. gkpatel@cardiff.ac.uk |
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Abstract: | We report an 81-year-old female with a heterozygous factor V Leiden mutation who developed purpura fulminans. Digital necrosis, a characteristic clinical feature of purpura fulminans was prominent. Purpura fulminans is more common in children and adult cases are rare. Of eight reported cases of purpura fulminans resulting from a heterozygous factor V Leiden mutation recorded in the literature, only two were in adults: 40 and 42 years of age, respectively. This is the first report of this condition arising in a patient in her eighties. |
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Keywords: | digital necrosis factor V Leiden protein C purpura fulminans |
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