| 粉防己碱对原发性高血压患者前列腺素和脂质代谢的影响 |
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| 引用本文： | 陈树元,叶松柏. 粉防己碱对原发性高血压患者前列腺素和脂质代谢的影响[J]. 中国药理学通报, 1992, 0(6) |
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| 作者姓名： | 陈树元 叶松柏 |
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| 作者单位： | 第一军医大学南方医院药学部 广州510515(陈树元)，华西医科大学 成都610041(叶松柏) |
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| 摘 要： | 观察40例原发性高血压患者循环血中6—Keto—PCF_(1α)LPO,TXB_2及血脂水平。随机将病人分为粉防己碱组(每次0.1～0.2g。Tid,po,n=22)和硝苯啶组(每次5～20mg,Tid,po,n=18),治疗3个月,发现两药在降压的同时尚使TXB_2、LPO、apoB_(100)水平降低,使6—KetO—PGF(1u)和apoA;水平升高.硝苯啶还有降低血脂作用,而粉防己碱则无此作用。提示粉防己碱与硝苯啶有促进PGI_2合成,抑制TXA_a释放和抗过氧化作用。
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| 关 键 词： | 粉防已碱 原发性高血压 过氧化脂质 前列腺素 载脂蛋白 |
The effects of tetrandrine on metabolism of prostaglandin and lipids in patients with essential hypertension |
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| CHEN Shu-Yuan,YE Song-Bai. The effects of tetrandrine on metabolism of prostaglandin and lipids in patients with essential hypertension[J]. Chinese Pharmacological Bulletin, 1992, 0(6) |
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| Authors: | CHEN Shu-Yuan YE Song-Bai |
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| Abstract: | The effects of tetrandrine on serum TXB2, 6 - Keto - PGF1α, LPO and lipids in patients(n= 40)with essential hypertension has been studied. The results showed that: (1) The levels of serum 6 - Keto -PGF1α,apoA1 in EHT were lower and the level of serum TXB2,LPO and apoB100 were higher than those in control. (2)Patients with essential hypertension treated with tetrandrine (0.1 ~ 0. 2g,tid,po)for 3 mon revealed that thelevels of TXB2, LPO and apoB100 were decreased, and the levels of apoA1 and 6 - Keto - PGF1α were increased. In conslusion,tetrandrine stimulated the synthesis of PGI2 and inhibited the release of TXA2 and normalized the metabolism of lipids in patients with essential hypertension. |
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| Keywords: | tetrandrine essential hypertension apoB_(100) apoA_1 prostaglandins h-pidic peroxidation |
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