帕金森病患者视觉整体与局部认知功能研究

目的 探讨帕金森病(PD)患者视觉整体与局部认知功能。方法 利用中国科技大学研究生院认知实验室设计的整体与局部认知功能检查软件对30例PD患者和31例对照进行检查。结果 PD患者的反应时间(RT)较对照组无显著性差异(P>0.05)。进一步研究发现左侧肢体起病PD患者RT较对照组延长,右侧起病PD患者RT较对照组缩短,但除左侧起病PD患者整体(大小箭头方向一致)情况外,均无显著性差异。将左侧和右侧起病的PD患者进行对比发现,左侧起病患者各项RT(除局部大小箭头方向不一致情况外)均较右侧起病患者显著延长(P<0.05)。结论右侧基底节参与了视觉整体与局部的认知加工,左侧基底节可能对右侧基底节有抑制性调节作用。

The visual global and local cognitive functions in the patients with Parkinson''''s disease

Objective To study the visual global and local cognitive functions in the patients with Parkinson's disease (PD). Methods The visual cognitive software, which was devised by the Cognition Laboratory of National Science and Technology University, was used and 30 PD patients and 31 normal controls (NC) were enrolled in the study. Results No Significant difference on reaction time (RT) of Visual global and local processing was found between PD patients and NC. Furthermore, the PD patients were divided into two groups: left side onset (LPD) and right side onset (RPD). The RT was longer in LPD than in NC and the RT was shorter in RPD than in NC. But there were no significant differences between PD patients and NC except global processing (big and small arrows at the same direction) in LPD. The RT was significantly longer in LPD than in RPD except local processing (big and small arrows at different direction) (P<0.05). Conclusions The present study indicated that right basal ganglia might play a role in the global and local processing and left basal ganglia might modulate (inhibit) the processing activity of right side.