| 银屑病患者T淋巴细胞集落形成及IL－2R的研究 |
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| 引用本文： | 陆前进,张其亮,文海泉,黄力人. 银屑病患者T淋巴细胞集落形成及IL－2R的研究[J]. 中南大学学报(医学版), 1995, 0(1) |
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| 作者姓名： | 陆前进 张其亮 文海泉 黄力人 |
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| 作者单位： | Department of Dermatology，The Second Affiliated Hospital，Hunan Medical University |
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| 摘 要： | ２１例银屑病患者及１０例正常人外周血Ｔ淋巴细胞集落形成单位（ＴＬ－ＣＦＵ）及白细胞介素２受体（ＩＬ－２Ｒ）表达检测结果显示，银屑病患者ＴＬ－ＣＦＵ数及ＩＬ－２Ｒ表达均低于正常人（Ｐ均＜０．０１），且进行期低于静止期（Ｐ＜０．０１，Ｐ＜０．０１）。寻常型与脓疤型比较均无明显差异（Ｐ均＞０．０５）。ＩＬ－２Ｒ表达与ＴＬ－ＣＦＵ数呈正相关（Ｐ＜０．０１）。表明银屑病患者细胞免疫功能低下，且Ｔ细胞免疫功能在祖细胞水平即有损害
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| 关 键 词： | 银屑病：T淋巴细胞集落形成；白细胞介素2；受体，白细胞介素2 |
STUDY ON T LYMPHOCYTTE COLONY FORMATION AND IL-2R IN RATIENTS WITH PSORIASIS |
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| Lu Qianjin,ZhangQiliang,Huang Liren. STUDY ON T LYMPHOCYTTE COLONY FORMATION AND IL-2R IN RATIENTS WITH PSORIASIS[J]. Journal of Central South University. Medical sciences, 1995, 0(1) |
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| Authors: | Lu Qianjin ZhangQiliang Huang Liren |
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| Abstract: | lymphocyte colony formation unit(TL-CFU)and interleukin 2 receptor(IL-2R)weredetermined in 21 cases of patients with psoriasis and 10 cases of normal controls.The resultsshowed that the number of TL-CFU and the expression of IL-2R were significantly lower inpatients with psoriasis than that in healthy controls(P<0.01,P<0.01).So was the activestage group in comparison with the resting stage group(P<0. 01,P<0.01),but there wasno difference between psoriasis vulgaris and psoriasis pastulosa(P>0.05),the expression ofIL-2R was positively correlated to the number of TL-CFU(P<0.01).These findingssuggested that the dysfunction of cellular immunity seen in patients with psoriasis tookplace at the level of T lymphocyte pregeniter. |
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| Keywords: | psorlasis T lymphocye coloy formation interleukin-2 receptors interleukin-2 |
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