| 缺血预处理对大鼠脑钙调神经磷酸酶活性的影响 |
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| 引用本文： | 郑梅,张敏,朱宁,张纬,孙晓明,于公元. 缺血预处理对大鼠脑钙调神经磷酸酶活性的影响[J]. 武警医学院学报, 2009, 18(5): 380-381,414 |
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| 作者姓名： | 郑梅 张敏 朱宁 张纬 孙晓明 于公元 |
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| 作者单位： | 1. 天津医科大学生化教研室,天津,300070
2. 武警医学院生化教研室,天津,300162 |
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| 基金项目： | 天津市教育委员会科研项目 |
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| 摘 要： | 【目的】观察脑缺血和缺血预处理对大鼠脑钙调神经磷酸酶（CaN）活性的影响，探讨CaN在脑缺血中的作用。【方法】制备大鼠大脑缺血及缺血预处理模型，分步离心提取蛋白，应用紫外分光光度法测定各组CaN在大鼠脑中的活性。【结果】缺血组CaN活性明显低于正常组（P〈0．05），缺血预处理组CaN活性明显高于缺血组（P〈0．05）。【结论】实验结果表明缺血预处理可保护大鼠脑缺血时CaN的活性。
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| 关 键 词： | 缺血预处理 钙调神经磷酸酶 脑 |
Effects of ischemic preconditioning on the activity of calcineurin in the brain of rat |
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| ZHENG Mei,ZHANG Min,ZHU Ning,ZHANG Wei,SUN Xiao-ming,YU Gong-yuan. Effects of ischemic preconditioning on the activity of calcineurin in the brain of rat[J]. Acta Academiae Medicinae CPAPF, 2009, 18(5): 380-381,414 |
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| Authors: | ZHENG Mei ZHANG Min ZHU Ning ZHANG Wei SUN Xiao-ming YU Gong-yuan |
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| Affiliation: | (Department of Biochemistry, Tianjin Medical University, Tianjin 300070, China) |
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| Abstract: | [ Objective] To observe the effects of ischemic preconditioning on the activity of calcineurin in the brain of rat. [Methods] Focal cerebral ischemia and cerebral ischemia preconditioning in normal rats were induced. The activity of calcineurin in each group was examined. [ Results] The activity of calcineurin in cerebral ischemia group was significantly lower than that in control group （ P 〈 0.05）. [ Conclusions] These results suggest that the activity of calcineurin in cerebral ischemia is protected by ischemic preconditioning. |
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| Keywords: | Ischemic preconditioning Calcineurin Cerebral |
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