| 南方汉族慢性髓细胞性白血病与HLA-DPB1 等位基因的相关性研究 |
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| 引用本文： | 田红,周淑芸,刘泽寰,付永贵,吕凤娟,林蒋海,徐安龙. 南方汉族慢性髓细胞性白血病与HLA-DPB1 等位基因的相关性研究[J]. 中国实验血液学杂志, 2003, 11(3): 266-268 |
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| 作者姓名： | 田红 周淑芸 刘泽寰 付永贵 吕凤娟 林蒋海 徐安龙 |
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| 作者单位： | 1. 第一军医大学南方医院血液科,广州,510515
2. 中山大学生命科学院,广州,510275 |
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| 基金项目： | 国家杰出青年基金资助项目 编号 3 972 5 0 0 7 |
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| 摘 要： | 为了探讨慢性髓细胞性白血病(CML)与人类白细胞抗原(HLA)DPB1基因的相关性和分析其遗传易感性，采用测序分型技术(SBT)对86例主要为广东籍的南方汉族CML患和82例健康对照进行HLA-DPB1基因分型。结果表明HLA-DPB1*1301和DPB1*20011的基因频率在病例组高于对照组。结论：这些等位基因与CML间可能存在正相关关系。
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| 关 键 词： | 慢性髓细胞性白血病 HLA—DPB1等位基因 基因频率 |
| 文章编号： | 1009-2137(2003)03-0266-03 |
| 修稿时间： | 2003-02-27 |
Association of HLA-DPB1 Alleles with Chronic Myelogenous Leukemia in Southern Chinese Hans |
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| TIAN Hong,ZHOU Shu Yun,LIU Ze Huan ,FU Yong Gui ,LU Feng Juan ,LIN Jiang Hai ,XU An Long. Association of HLA-DPB1 Alleles with Chronic Myelogenous Leukemia in Southern Chinese Hans[J]. Journal of experimental hematology, 2003, 11(3): 266-268 |
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| Authors: | TIAN Hong ZHOU Shu Yun LIU Ze Huan FU Yong Gui LU Feng Juan LIN Jiang Hai XU An Long |
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| Affiliation: | Department of Hematology, Nanfang Hospital, The First Military Medical University, Guangzhou, 510515, China. |
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| Abstract: | To clarify the association between HLA DPB1 alleles and chronic myelogenous leukemia (CML) in South Chinese, the allelic types of HLA DPB1 were detected by sequence based typing (SBT) in 86 patients with CML and 82 healthy individuals from Southern China. The results showed that the frequencies of HLA DPB1*1301 and DPB1*20011 were higher in patients with CML in comparison with those of healthy individuals. It is concluded that positive association may exist between certain HLA DPB1 alleles and CML. |
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| Keywords: | chronic myelogenous leukemia HLA DPB1 allele gene frequency |
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