| 新生鼠脑缺血再灌注后海马CA1区突触素的表达及意义 |
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| 引用本文： | 宋文秀,曹云涛,刘华庆. 新生鼠脑缺血再灌注后海马CA1区突触素的表达及意义[J]. 医学争鸣, 2004, 25(16): 1467-1469 |
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| 作者姓名： | 宋文秀 曹云涛 刘华庆 |
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| 作者单位： | 珠海市斗门区遵义医学院第五附属医院儿科,广东,珠海,519100;遵义医学院附属医院,儿科,贵州,遵义,563003;遵义医学院附属医院,病理科,贵州,遵义,563003 |
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| 基金项目： | 贵州省卫生厅资助项目 (D 1 4 3)，贵州省省教育厅立项 |
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| 摘 要： | 目的 :观察新生Wistar大鼠脑缺血再灌注后海马CA1区突触素的表达 .探讨中枢神经系统的可塑性 .方法 :应用免疫组化方法观察新生鼠脑缺血再灌注后不同时点脑组织突触素的表达 .结果 :缺血再灌注 3d突触素表达开始增高 ,7d达高峰 ,1 4d时免疫活性仍高 ,其矫正吸光度值与对照组比较有显著性差异 (P <0 .0 1 ) .结论 :新生Wistar大鼠脑神经细胞损伤后具有修复的可塑性 ,其时间持续至缺血再灌注后 1 4d .突触素检测能较好地反映神经元和轴突的代偿再生情况
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| 关 键 词： | 脑缺血 突触膜糖蛋白 海马CA1区 大鼠 Wistar 动物 新生 |
| 文章编号： | 1000-2790(2004)16-1467-03 |
| 修稿时间： | 2004-01-13 |
Expression of Syn in hippocampal CA1 region after cerebral ischemia-reperfusion in newborn rats and its significance |
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| SONG Wen Xiu ,CAO Yun Tao ,LIU Hua Qing. Expression of Syn in hippocampal CA1 region after cerebral ischemia-reperfusion in newborn rats and its significance[J]. Negative, 2004, 25(16): 1467-1469 |
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| Authors: | SONG Wen Xiu CAO Yun Tao LIU Hua Qing |
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| Affiliation: | SONG Wen Xiu 1,CAO Yun Tao 2,LIU Hua Qing 3 1Department of Pediatrics,5th Affiliated Hospital of Zunyi Medical College,Zhuhai 519100,China,2Department of Pediatrics,3Department of Pathology,Affiliated Hospital of Zunyi Medical College,Zunyi 563003,China |
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| Abstract: | AIM: To observe synaptophysin(Syp)expression in hippocampal CA1 region of 7 day old Wistar rats after cerebral ischemia reperfusion. METHODS: Immunohistochemical method was used to measure the expression of Syp in the hippocampal CA1 region after reperfusion. RESULTS: The expression of Syp in hippocampal CA1 region in cerebral ischemia reperfusion group increased at 3 d after reperfusion and reached the highest level at 7 d. The corrected optical density(COD) value was significantly higher than that in the sham operation group ( P <0.01). CONCLUSION: Neural plasticity occurrs at 3 d and continues to 14 d after cerebral ischemia reperfusion in newborn rats. Syp is a good index indicating the regeneration of neuron and nervous axons. |
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| Keywords: | cerebral ischemia synaptophysin hippocampal CA1 region rats Wistar animals newborn |
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