茉莉根提取物抗实验性心律失常的研究

目的研究茉莉根提取物的抗实验性心律失常作用。方法取茉莉根提取物分别注入由氯仿诱发心室颤动的小鼠、乌头碱诱发心律失常的大鼠、氯化钙诱发心室颤动的大鼠和肾上腺素诱发心律失常的家兔体内,观察其对实验动物心律失常的影响。结果①茉莉根提取物(腹腔注射2.0mg/kg、3.0mg/kg)对氯仿诱发的小鼠心室颤动有明显的预防作用;②茉莉根提取物(静脉注射1.0mg/kg、1.5mg/kg)对乌头碱诱发的大鼠心律失常有明显的治疗效果;③茉莉根提取物(静脉注射2.0mg/kg、3.0mg/kg)对氯化钙诱发的大鼠心室颤动具有预防作用,且能明显地降低大鼠的死亡率;④茉莉根提取物(静脉注射2.0mg/kg、3.0mg/kg)还能对抗肾上腺素诱发的家兔心律失常。以上作用具有明显的剂量依赖性。结论茉莉根提取物有明显的抗心律失常作用,可能与其抑制Na+内流、Ca2+内流及与阻断β-肾上腺素受体有关。

Antiarrhythmic effect of aqueous extract of radix jasmini sambac

Objective To investigate the antiarrhythmic effect of radix jasmini sambac. Methods The extract of radix jasmini sambac was injected into the body of the mice with ventricular fibrillation inducted by chloroform, the rats with arrhythmia induced by aconitine, the rats with ventricular fibrillation inducted by calcium chloride, the domestic rabbits with arrhythmia induced by adrenaline respectively, observing the influence on the experimental animal arrhythmia. Results It has been found that radix jasmini sambac was markedly effective in preventing ventricular fibrillation induced by chloroform in mice and arrhythmia induced by aconitine in rats. Radix jasmini sambac could prevent ventricular fibrillation induced by calcium chloride in rats, as well as obviously reduced the death rate of rats. In addition,the arrhythmia induced by adrenaline in rabbits was antagonized by radix jasmini sambac. The above-mentioned effects were all dose-dependent. Conclusion Radix jasmini sambac has obviously a protective effect against drugs-induced arrhythmia, which may be related to its inhibition of Na+ or Ca2+ influx and its blocking β-adrenergic receptor.