| 龙芽楤木总甙对前列腺素及环核苷酸的影响 |
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| 引用本文： | 任骏,程锦轩,王振纲. 龙芽楤木总甙对前列腺素及环核苷酸的影响[J]. 中国药理学通报, 1988, 0(3) |
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| 作者姓名： | 任骏 程锦轩 王振纲 |
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| 作者单位： | 中国医学科学院基础医学研究所,中国医学科学院基础医学研究所,中国医学科学院基础医学研究所 中国协和医科大学 北京 中国协和医科大学八二级学生,中国协和医科大学 北京,中国协和医科大学 北京 |
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| 摘 要： | 用龙芽楤木总甙的生理盐水溶液给小鼠ip,连续7d。实验证明:龙芽楤木总甙能显著刺激前列腺素E_2和F_(2a)的合成,诱导cAMP含量明显增加,cGMP含量明显下降。对组织胺释放无影响,从而为在分子水平探讨该药作用机理提供了依据。
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| 关 键 词： | 龙芽(木 匆 心)木总甙 前列腺素E_2 前列腺素F_(2α) 环磷腺苷酸 环磷鸟苷酸 组胺 |
EFFECT OF TOTAL ARALOSIDES ON PROSTAGLANDINS AND CYCLIC NUCLEOTIDE |
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| Ren Jun Cheng Jinxuan , Wang Zhengang. EFFECT OF TOTAL ARALOSIDES ON PROSTAGLANDINS AND CYCLIC NUCLEOTIDE[J]. Chinese Pharmacological Bulletin, 1988, 0(3) |
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| Authors: | Ren Jun Cheng Jinxuan & Wang Zhengang |
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| Abstract: | The total aralosides extracted from Aralia elata (Miq) Seem. were studied in mice ( 50 mg/kg/d for 7 d ) to investigate the pharmacological mechanisms on the molecular level.The results showed that aralosides can obviously stimulate the production of PGE2、PGF2, and cAMP but reduce the cGMP level and nave no effect on histamine release.It is suggested that the changes in the level of cyclic nucleotide might be due to the alternations of PGs, which is now been suspected as the "Second Messenger" . These findings could explain in part the pharmacological activities of aralosides on the molecular level. |
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| Keywords: | Aralosides Prostaglandin E_2 (PGE_2) Prostaglandin F_(2α) ( PGF_(2α) ) cAMP cGMP Histamine |
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