Non-linear electroencephalogram dynamics in patients with spontaneous nocturnal migraine attacks |
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Authors: | Strenge H Fritzer G Göder R Niederberger U Gerber W D Aldenhoff J |
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Institution: | Department of Psychiatry, Yokohama City University, School of Medicine, Yokohama, Japan. |
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Abstract: | We investigated immunohistochemically the localization of type 1 plasminogen activator inhibitor (PAI-1) in rat and human brain tissues. In rat, neurons and astrocytes were stained positively for PAI-1 after colchicine treatment. In post-mortem human brain, neurons were stained for PAI-1 but the number of positive neurons varied greatly from case to case. PAI-1 positive astrocytes occurred in the white matter lesions of some patients. In Alzheimer's disease, weak PAI-1 labeling was seen in association with senile plaques and ghost tangles. The present results support a notion that PAI-1 and its target proteases such as plasminogen activators and thrombin are involved in a variety of physiological and pathological processes in brain. |
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