血塞通联合低分子肝素钙治疗急性脑梗死临床观察及对血浆cAMP、cGMP的影响

目的:观察血塞通注射液联合低分子肝素钙治疗急性脑梗死的临床疗效及对血浆cAMP、cGMP的影响。方法:选择150例急性脑梗死随机分为治疗组(血塞通及低分子肝素钙)80例和常规治疗对照组,治疗前及治疗后14d进行疗效评定,并监测实验室指标进行统计学分析。结果:治疗组的神经功能缺损评分减少的百分率明显大于对照组(P<0.05),血液流变学指标的治疗组均有明显改变,血小板计数和出凝血时间无明显变化,cAMP较前升高、cGMP较前下降。结论:血塞通联合低分子肝素钙在脑梗死治疗中,有肯定的疗效,且无明显副作用。

Clinical Observation on the Effects of Xuesetong Iujection and LMWHC and Ecffect on cAMP and cGMP In plasma In Treating ACI Patients

Objective: To observe the clinical effectiveness of Xuesetong injection and Low-molecular-weight heparin calcium in treating the patients with acute cerebral infarction and detect the effect on the content of cAMP and cGMP in plasma. Method: 150 cases of acute cerebral infarction ( ACI ) were randomly divided into 2 groups the research group ( group of Xuesetong and Low-molecular-weight Heparin calcium LMWHC ) in 80 cases, and routine treatment control group ( 70 cases). The clinical effectiveness was observed after treatment for 28 days and caboratong indexes were monitored and analyzed statistically. Result: The improvement of scores of nervous system damage and the change of hemorheological inbexes of the treatment group were better than those of the control group, but the platelet count the bleeting eire and coagulation tire had no evident charnes plasma cAMP and cGMP level went down in the eese group. Conclusion: Xuesetong injection and LMWHC in treating patients with acute cerebral infarction is effective and little adverse reactions occurred.