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Relative and disease-free survival for breast cancer in relation to subtype: a population-based study |
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| Authors: | Pamela Minicozzi Francesca Bella Angela Toss Adriano Giacomin Mario Fusco Maurizio Zarcone Rosario Tumino Fabio Falcini Rosaria Cesaraccio Giuseppa Candela Francesco La Rosa Massimo Federico Milena Sant |
| Institution: | 1. Analytical Epidemiology and Health Impact Unit, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133, Milan, Italy 2. Department of Oncology, Hematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy 3. Piedmont Cancer Registry, Province of Biella (CPO), Epidemiology Unit, Biella, Italy 4. Campania Cancer Registry, Local Health Unit Napoli 3 South, Brusciano, Naples, Italy 5. Palermo Breast Cancer Registry, Department of Oncology, “ARNAS Civico” Hospital, Palermo, Italy 6. Epidemiology and Prevention Unit, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy 7. Cancer Registry and Histopathology Unit, “MP Arezzo” Civic Hospital, Provincial Health Unit, Ragusa, Italy 8. Romagna Cancer Registry, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Forlì, Italy 9. Sassari Cancer Registry, Epidemiology Unit, Local Health Unit 1, Sassari, Italy 10. Trapani Cancer Registry, Provincial Health Unit, Erice, Trapani, Italy 11. Department of Surgical and Medical Specialties and Public Health, University of Perugia, Perugia, Italy |
| Abstract: | PurposeNo population-based study has investigated breast cancer (BC) subtypes defined by including Ki67. The aim of this study was to evaluate the relative proportions of immunohistochemical subtypes and differences in relative and disease-free survival between subtypes, in relation to patient and other cancer characteristics in Italian BC patient.MethodsInformation on estrogen, progesterone, human epidermal growth factor (HER2), Ki67, and relapses was obtained for 3,381 cases, sampled randomly and anonymously from cases diagnosed in 2003–2005 in nine Italian cancer registries. Relative excess risks (RERs) of death and risks of relapse 5 years after diagnosis were estimated.ResultsLuminal A cancers were 42 % of the total, luminal B 27 %, luminal-HER2 14 %, triple-negative 11 %, and HER2-enriched 7 %. For non-metastatic (3,302) cases, 4 and 7 % developed locoregional and distant metastases, respectively. RERs of death and risks of relapse were significantly greater for all cancer subtypes than luminal A, particularly for triple-negative and HER2-enriched cancers, which were more frequent in women <40 years.ConclusionsOur population-based findings confirm that subtype is an independent prognostic factor for BC. Triple-negative and HER2-enriched subtypes would benefit from the development and wide application, respectively, of targeted treatments, which would also improve survival for younger patients. |
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