完全动脉化辅助性肝移植治疗大鼠急性肝功能衰竭的实验研究

目的　探讨辅助性肝移植门静脉动脉化加肝动脉血供对急性肝功能衰竭治疗作用。方法　切除85 %肝脏诱导大鼠肝衰 ,将 30 %肝脏移植于残肝下方 ,通过右肾动脉行移植肝门静脉动脉化并建立肝动脉血供。观察肝衰组和移植组大鼠存活率、肝功能和结构改变。结果　移植组 2周存活率为 73 3% ,肝衰组 4 8h存活率 0 % (P <0 0 5 )。移植术后 14d残肝明显增生 ,肝功恢复正常 ,移植肝萎缩纤维化。结论　辅助性肝移植门静脉动脉化为急性肝功衰竭提供了有效的支持作用 ,使原肝再生功能恢复而移植肝萎缩

Treatment of Acute Liver Failure by Auxiliary Liver Transplantation with Full Arterialization of the Graft

Objective To explore the effect of auxiliary partial liver transplantation in the treatment of acute liver failure (ALF). Methods ALF was induced by resection of about 85% liver tissue. 30% of partial liver graft were implanted below the host residual liver. The portal vein was arterilized via right renal artery. The survival rate, biochemical test for liver function and pathological changes of liver were studied. Results The survival rate in 2 weeks was 73.3% in the treated group compared with 0 in 48 hours in the control group (P<0.05). 14 days after operation, the host liver regenerated obviously and liver function recovered while the graft shrank and became fibrosis gradually. Conclusion Auxiliary partial heterotopic liver transplantation with portal vein arterialization might provide and effective support for ALF and allow regeneration of the native liver.