中药三七注射液对显性糖尿病肾病并高凝状态的影响

目的：观察血栓通注射液治疗显性糖尿病肾病并血液高凝状态的疗效。方法：６０例显性糖尿病肾病并高凝状态患者随机分为血栓通注射液治疗组（治疗组）和丹参注射液对照组（对照组），每组各３０例。对比观察了两组的总疗效及高凝状态的治疗效果。结果：治疗组总疗效明显高于对照组（Ｐ＜０．０１）。两组均可显著降低尿蛋白、提高血浆白蛋白、增加尿量，治疗组及对照组治疗后相比较，治疗组的利尿作用更明显（Ｐ＜０．０５）。无论治疗组或对照组均可明显改善血液高凝状态，多项指标治疗前后比较有统计意义，治疗组及对照组疗后相比较，治疗组降低血浆纤维蛋白原及凝血酶原时间的作用较对照组更显著（Ｐ＜０．０５）。结论：血栓通注射液可提高显性糖尿病肾病的疗效、明显地改善血液高凝状态。

Effect of XEU SHUAN TONG Injection on Overt Diabetic Nephropathy with Hypercoagulability

Objective: To observe the curative effect of XEU SHUAN TONG injection on overt diabetic nephropathy(DN)with hypercoagulability. Methods: Sixty overt DN patients with hypercoagulability were randomly divided into XEU SHUAN TONG injection group( treatment group)and DAN SI-LEN injection group( control group), each with 30 patients. The total effective rate and the curative rate of hypercoagulability were observed during treatment. Results: The total effective rate in treatment group is significantly higher than that in control group( P <0. 01). Urinary protein was significantly reduced. Plasma albumin and urine volume significantly increased in both groups. Increase of urine volume in the treatment group was greater than that in control group( P <0. 05). Both treatment group had significant improvement in bkxxi hypercoagulability after treatment. Reduction in fibrinogen and platelet was more obvious in the treatment group than that in control group( P< 0.05). Conclusions: XEU SHUAN TONG injection obviously improves blood hypercoagulability in overt DN.