慢性阻塞性肺疾病患者C反应蛋白及肺功能变化的临床意义

目的探讨慢性阻塞性肺疾病（chronic obstructive pulmonary disease COPD）稳定期及急性加重期患者血清C反应蛋白（C-reactive protein CRP）和肺功能变化及其临床意义。方法检测54例COPD急性加重期患者（AE-COPD）与50例缓解期患者的血清CRP水平、白细胞计数（WBC）、中性粒细胞比值（NE%）及肺功能（Lung function）。结果 AECOPD患者CRP为（52.9±15.6）mg/L,缓解期为（5.9±4.8）mg/L,差异有统计学意义（P〈0.01）;AECO-PD患者CRP阳性率为92.59%,显著高于WBC和NE%的阳性率（P〈0.01和P〈0.05）,肺功能损害严重者CRP水平较高。结论 COPD患者CRP在急性发作期可以显著增高,CRP可以作为AECOPD的优选指标。C-反应蛋白水平增高是呼吸功能受损强有力和独立的影响因素。

Changes of the level of C reactive protein and lung function in patients with chronic obstructive pulmonary disease and its clinical significance

Objective To observe C reactive protein(CRP) level in patients with chronic obstructive pulmonary disease(COPD) and to investigate its clinical significance.Methods The serum CRP level of 54 patients with COPD at acute exacerbation(AECOPD) and 50 patients at stable stage were measured.The white blood cells(WBC) and percentage of neutrophils(NE%) were collected.Results The serum CRP level of AECOPD patients(54.5±11.45) mg/L was significantly higher than that of the patients at the stable stage(6.4±5.80) mg/L(P<0.01).The positive rate of the serum CRP of AECOPD patients was significantly higher(92.59%) than that of WBC(P<0.01) and NE%(P<0.05).Conclusion The serum CRP level of COPD patients increases significantly at the acute exacerbation stage.