微创颅内血肿清除术联合依达拉奉治疗老年急性高血压性脑出血疗效分析

目的:探讨微创颅内血肿清除术联合依达拉奉治疗对老年急性高血压性脑出血患者血清炎症因子和神经功能恢复的影响。方法:老年急性高血压性基底核区脑出血患者45例随机分为对照组25例和观察组20例;对照组给予微创血肿清除术和常规治疗,观察组同时给予依达拉奉30mg静脉滴注,2次/天,共14d;治疗前及治疗后14、28d,检测并比较2组患者的血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平、中国脑卒中临床神经功能缺损程度评分量表(CSS)评分及临床有效率。结果:治疗前2组hs-CRP、TNF-α、IL-6水平及CSS评分差异无统计学意义;治疗后2组上述指标均较治疗前降低(P<0.05),且观察组改善较对照组明显(P<0.05),观察组临床有效率高于对照组(P<0.05)。结论:微创血肿清除术联合依达拉奉治疗能更好地清除老年急性高血压性脑出血患者血清炎症因子,改善神经功能恢复,疗效优于单独使用微创血肿清除术。

Therapeutic Effect of Minimally Invasive Evacuation of Intracranial Hematoma Combined with Administration of Edaravone on Elderly Patients with Acute Hypertensive Intracerebral Hemorrhage

Objective: To investigate the effects of minimally invasive evacuation of intracranial hematoma combined with administration of edaravone on the levels of serum inflammatory cytokines and the neurologic function recovery in elderly patients with acute hypertensive intracerebral hemorrhage.Methods:Forty-five elderly patients with acute hypertensive cerebral hemorrhage in the basal ganglia were randomly divided into the control group(n=25) and the observation group(n=20).The patients in the control group were given minimally invasive evacuation of intracranial hematoma and conventional treatment,while the patients in the observation group were given edaravone treatment in addition to the basic treatment above(30 mg,intravenous,semidaily,for 14 days).The serum levels of hs-CRP,TNF-α and IL-6,scores of CSS and total clinical efficacy were compared between the two groups before and at 14,28 days after treatment.Results:Before treatment,the serum levels of hs-CRP,TNF-α and IL-6 and scores of CSS in the two groups were similar.When compared with those before treatment,the serum levels of hs-CRP,TNF-α and IL-6 and scores of CSS in the both groups were decreased after treatment(P<0.05).Patients in the observation group had lower serum levels of hs-CRP,TNF-α and IL-6 and scores of CSS and higher effective rate than those in the control group(P<0.05).Conclusion:Minimally invasive evacuation of intracranial hematoma combined with administration of edaravone helps to decrease the serum levels of hs-CRP,TNF-α and IL-6 and promote the neurological function recovery of elderly patients with acute hypertensive intracerebral hemorrhage.